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Diabetes mellitus results in severe metabolic imbalances and pathological changes in many tissues. Oxidative stress has been shown to play an important role in the etiology of diabetes and diabetic complications. Diabetics exhibit high-oxidative stress due to persistent and chronic hyperglycemia, thereby reducing the activity of the antioxidative defense system and thus promoting free radical generation.
Black seed oil may be of some benefit to people with diabetes, according to an animal-based study published in Planta Medica in 2002. In tests on diabetic rats, the study's authors found that black seed oil may help lower blood sugar levels.
Several interactive pathogenetic mechanisms of diabetic peripheral neuropathy have been identified in both human and murine models and persistent hyperglycaemia has been regarded as a primary risk factor for neuropathy. Long-term hyperglycaemia can lead to subsequent enhanced oxidative stress, increased aldose reductase activity, and accumulation of advanced glycation endproducts (AGE). As a result, it could induce progressive damage to the peripheral sensory and autonomic nervous systems. To date, except for rigorous glycaemic control, there are few means to affect or slow the natural progression of diabetic peripheral neuropathy owing to limitations of the current and often inadequate drug therapy.
|Video Source Credit: Diabetes UK - diabetes.org.uk|
Total: 25.8 million children and adults in the United States—8.3% of the population—have diabetes.
Diagnosed: 18.8 million people
Undiagnosed: 7.0 million people
Prediabetes: 79 million people*
New Cases: 1.9 million new cases of diabetes are diagnosed in people aged 20 years and older in 2010.
* In contrast to the 2007 National Diabetes Fact Sheet, which used fasting glucose data to estimate undiagnosed diabetes and prediabetes, the 2011 National Diabetes Fact Sheet uses both fasting glucose and A1C levels to derive estimates for undiagnosed diabetes and prediabetes. These tests were chosen because they are most frequently used in clinical practice.