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Diabetes mellitus results in severe metabolic imbalances and pathological changes in many tissues. Oxidative stress has been shown to play an important role in the etiology of diabetes and diabetic complications. Diabetics exhibit high-oxidative stress due to persistent and chronic hyperglycemia, thereby reducing the activity of the antioxidative defense system and thus promoting free radical generation.
Several interactive pathogenetic mechanisms of diabetic peripheral neuropathy have been identified in both human and murine models and persistent hyperglycaemia has been regarded as a primary risk factor for neuropathy. Long-term hyperglycaemia can lead to subsequent enhanced oxidative stress, increased aldose reductase activity, and accumulation of advanced glycation endproducts (AGE). As a result, it could induce progressive damage to the peripheral sensory and autonomic nervous systems. To date, except for rigorous glycaemic control, there are few means to affect or slow the natural progression of diabetic peripheral neuropathy owing to limitations of the current and often inadequate drug therapy.
However, in a recent animal study, scientists found Nigella Sativa (also known as Black Seed or Black Cumin) and its pharmacologically active substance thymoquinone, affected blood glucose levels, and insulin. Furthermore, they suggested that the antioxidant activity of Black Seed may alleviate damage to b-cells in the pancreas. The study found less damage to tissues in diabetic animals treated with black seed and thymoquinone. The researchers concluded that the neuroprotective effects of thymoquinone and especially black seed are attributed to its direct and indirect antioxidant actions.
Babaei-Jadidi R, Karachalias N, Ahmed N, et al. Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. Diabetes. 2003 Aug;52(8):2110-20.
Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes. 1991 Apr;40(4):405-12.
Cameron NE, Cotter MA, Basso M, et al. Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats. Diabetologia. 1997 Mar;40(3):271-81.
Kanter M. Effects of Nigella Sativa and its major constituent, thymoquinone on sciatic nerves in experimental diabetic neuropathy. Neurochem Res. 2008 Jan;33(1):87-96.
Karachalias N, Babaei-Jadidi R, Ahmed N, et al. Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic rats. Biochem Soc Trans. 2003 Dec;31(Pt 6):1423-5.
Le PM, Benhaddou-Andaloussi A, Elimadi A, et al. The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat. J Ethnopharmacol. 2004 Oct;94(2-3):251-9.
[No authors listed] The effect of intensive diabetes therapy on the development and progression of neuropathy. The Diabetes Control and Complications Trial Research Group. Ann Intern Med. 1995 Apr 15;122(8):561-8.
[No authors listed] Failure of improved glycaemic control to reverse diabetic autonomic neuropathy. The St Thomas's Diabetic Study Group. Diabet Med. 1986 Jul-Aug;3(4):330-4.
Thorpe SR, Baynes JW. Role of the Maillard reaction in diabetes mellitus and diseases of aging. Drugs Aging. 1996 Aug;9(2):69-77.
Vague P, Coste TC, Jannot MF, et al. C-peptide, Na+,K(+)-ATPase, and diabetes. Exp Diabesity Res. 2004 Jan-Mar;5(1):37-50.
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I started taking the capsules this year during the cold and flu season to help my immune system. |
I started taking the capsules this year during the cold and flu season to help my immune system. For several weeks my co-workers were getting sick one after another, but I felt healthier than usual. I was amazed at how much stronger I felt! Eventually I did catch the cough/cold that had been going around (stress and extended lack of sleep will do that to you, no matter how strong your immunity). However, I got better at least 5 times faster than my co-workers with the same illness -- I only had to take 1 sick day. With a high-stress job, this is a supplement I don't want to go without. The other benefits (clearing skin, improving hair) are a nice bonus, too!
Amina Alexandria, Virginia |
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